近年来，外泌体的研究热度持续攀升，已成为当前生命科学和基础医学研究的一大热点，在 2023 年国家自然科学基金获批项目中，外泌体研究相关项目的总数近 390 个，立项的总金额突破 1.5 亿元。近日，Quantum Design中国顺利将NanoView全自动外泌体荧光检测分析系统安装于海军军医大学附属公利医院，并为用户进行详细的仪器介绍和操作培训，其优越的外泌体表征性能将为海军军医大学附属公利医院的研究平台添砖加瓦。
海军军医大学附属公利医院
全自动外泌体荧光检测分析系统是一款无需纯化的、全自动的可对单个外泌体进行表征分析的全新设备。该设备能够提供全方位的外泌体表征信息，包括外泌体粒径大小、计数、分布、携带蛋白表达、生物标志物（CD9，CD81，CD63等）共定位等。操作简单，结果可靠。短短三年，在世界范围内已有100多家实验室采用该设备，包括了著名的哈佛大学、约翰霍普金斯大学、康奈尔大学、洛杉矶儿童医院、麻省总医院、东京工业大学、首尔大学、新加坡国立大学、大阪大学、北京大学、上海交通大学、西安交通大学、中国海洋大学、重庆大学等，发表SCI已超过270篇，其中不乏顶级期刊如Cell、Nature、Journal of Extracellular Vesicles、Cancer Research、Nanoscale、ACS Nano、BMJ journal、Brain Behavior Immunity、Trends in Cancer 等。
设备安装完成
Quantum Design中国工程师向客户讲解实验原理
NanoView全自动外泌体荧光检测分析系统测试数据
2022-2023年Exoview高水平文章精选列表：
Richard J. R. Kelwick …& Paul S. Freemont. (2023) Opportunities to accelerate extracellular vesicle research with cell-free synthetic biology.Journal of Extracellular Vesicles.
Laurence Blavier …& Yves A. DeClerck. (2023) The capture of extracellular vesicles endogenously released by xenotransplanted tumours induces an inflammatory reaction in the premetastatic niche.Journal of Extracellular Vesicles.
Hongyun Wang ……& Junjie Xiao. (2022) Extracellular vesicles enclosed-miR-421 suppresses air pollution (PM2.5)-induced cardiac dysfunction via ACE2 signalling.Journal of Extracellular Vesicles.
Linglei Jiang……& Santosh Dhakal. (2022) A7 bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type and Delta variants.Journal of extracellular vesicles.
Shaobo Ruan, Nina Erwin, Mei He. (2022) Light-induced high-efficient cellular production of immune functional extracellular vesicles.Journal of extracellular vesicles.
Nasibeh Karimi ……& Cecilia Lässer. (2022) Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma – Contributions of platelet extracellular vesicles in plasma samples.Journal of Extracellular Vesicles.
Heikki Kyykallio ……& Pia R-M Siljander. (2022) A quick pipeline for the isolation of 3D cell culture-derived extracellular vesicles.Journal of Extracellular Vesicles.
Roberto Frigerio ……& Marina Cretich. (2022) Comparing digital detection platforms in high sensitivity immune-phenotyping of extracellular vesicles.Journal of Extracellular Vesicles.
Yael Hirschberg ……& Inge Mertens. (2022) Characterizing extracellular vesicles from individual low volume cerebrospinal fluid samples, isolated by SmartSEC.Journal of Extracellular Vesicles.
Sukhbir Kaur……& David D. Roberts. (2022) Single vesicle analysis of CD47 association with integrins and tetraspanins on extracellular vesicles released by T lymphoblast and prostate carcinoma cells.Journal of Extracellular Vesicles.
Simone M. Crivelli……& Erhard Bieberich. (2022) Function of ceramide transfer protein for biogenesis andsphingolipid composition of extracellular vesicles.Journal of Extracellular Vesicles.
Gi Beom Kim …& In-San Kim. (2023) Harnessing Oncolytic Extracellular Vesicles for Tumor Cell-Preferential Cytoplasmic Delivery of Misfolded Proteins for Cancer Immunotherapy.Small.
J. Klein, Y. Cao. (2023) Multi-Lipid Synergy In Cartilage Lubrication: Redundancy Or Evolution?Osteoarthritis and Cartilage.
Valerie DeLuca …& Michael E. Berens. (2023) Extracellular vesicles as a pharmacodynamic reporter in glioblastoma.Cancer Research.
Sarah Pike …& Liya Xu. (2023) Extracellular vesicles in diagnostic retinoblastoma aqueous humor correlate with disease stage and clinical outcome: a pilot study.Cancer Research.
D. Cookson …& Y. Ashraf Kharaz. (2023) The Biological Response Of Anterior Cruciate Ligamentocytes Following Treatment With Synovial Fluid Extracellular Vesicles.Osteoarthritis and Cartilage.
Mei Lu …& Yuanyu Huang. (2023) Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles.Acta Pharmaceutica Sinica B.
Luke C. McIlvenna ……& Martin Whitham. (2023) Single vesicle analysis reveals the release of tetraspanin positive extracellular vesicles into circulation with high intensity intermittent exercise.The Journal of Physiology.
Joseph Blommer ……& Dimitrios Kapogiannis. (2023) Extracellular vesicle biomarkers for cognitive impairment in Parkinson’s disease.BRAIN.
Tyler J ……& Atta Behfar. (2022) Exosome biopotentiated hydrogel restores damaged skeletal muscle in a porcine model of stress urinary incontinence.Npj Regenerative Medicine.
Min Han ……& Tao Xin. (2022) Three-Dimensional-Cultured MSC-Derived Exosome-Hydrogel Hybrid Microneedle Array Patch for Spinal Cord Repair.Nano Letters.
Zijian Yang ……& David A. Issadore. (2022) Ultrasensitive Single Extracellular Vesicle Detection Using High Throughput Droplet Digital Enzyme-Linked Immunosorbent Assay.Nano Letters.
服务推出至今，短短两年时间已经助力多个中国客户发表高水平文献！
■ 南方医科大学在《Chemical Engineering Journal 》发表文章
■ 南方医科大学珠江医院在《Bioengineering & Translational Medicine 》发表文章
■ 上海大学在《Journal of extracellular vesicles 》发表文章
■ 中国科学院深圳先进技术研究院在《Lab on a Chip 》发表文章
■ 北京天坛医院、国家纳米科学中心、北京航空航天大学在《Advanced Science 》发表文章
■ 同济大学附属上海市肺科医院、上海思路迪转化医学团队在《Journal of Nanobiotechnology 》发表文章
■ 山东千佛山医院在《NANO LETTERS 》发表文章
■ 陕西师范大学在《Food & Function 》发表文章
■ 南京大学在《Frontiers in Cell and Developmental Biology 》发表文章
■ 中山大学在《ACS NANO 》发表文章
■ 北京理工大学在《Acta Pharmaceutica Sinica B 》发表文章
■ 中南大学湘雅二医院在《International Journal of Nanomedicine 》发表文章
样机体验：
为了更好的服务中国客户，Quantum Design 中国子公司在北京建立了专业的客户服务中心，正式推出专业的全方位外泌体表征测试服务，您只需要极少量样品即可获得全方位的外泌体表征数据！欢迎各位老师参观试用！
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